- How accurate are drug tests?
- But what about external contamination?
- Which drug test should I use? How do I decide which is best for my company or organisation?
- When should I choose a hair test instead of urine or oral fluids?
- When should I NOT choose a hair test?
- I have read that cannabis cannot be detected in hair. Is this true?
- Can dyeing or bleaching hair affect the detection of drug use?
- How much hair is needed for a test?
- What if the donor has little or no head hair?
- What is the time period a standard test covers, and what variations can I request?
- Do hair tests discriminate between fair haired and dark haired people?
- What about civil liberties?
- What studies have been published on hair testing?
- Can passive smoking have an effect on results?
- How can you detect the difference between over-the counter drugs and illegal substances?
How accurate are drug tests?
Providing the sample is genuine, a competent laboratory performs the analysis
and the sample is both screened and confirmed, the chances of a 'false
positive' are very slim. Screening, the first stage in testing, sometimes
does not differentiate between drugs available over the counter and illicit
drugs from the same drug group. But a positive result from a screening
goes on to a second-stage confirmation test, using Gas Chromatography/Mass
Spectrometer analysis or similar, and the result is of 'fingerprint' accuracy
- clearly defining which drugs were detected in the sample. Top
But what about external contamination?
TrichoTech washes the hair samples prior to testing as an additional safeguard
for donors. Even if donors spend a lot of time with other people who smoke
or take illicit drugs, the GC/MS technique tests for metabolites, specific
compounds of drugs that are found only once those drugs have been ingested.
Top
Which drug test should I use? How do I decide which is best for my company or organisation?
Decide on what the purpose of the tests is - is it to check new recruits
are not bringing in a drug problem with them? Or to ensure an operator
is safe to drive or run machinery there and then? There may be a combination
of reasons - and you may therefore need a combination of test methods
at your disposal. Remember that most test kit suppliers have one range
of products, so they focus on their advantages - laboratories like TrichoTech
test and confirm samples from major oral fluids and urine kit providers. So
as well as offering hair analysis, we can provide an expert opinion on
the test programme that best fits your purpose. Our company policy is
to be honest about the limitations of each sample type and method - none
of them are perfect - so you have the information with which to make the
decision. Top
When should I choose a hair test instead of urine or oral fluids?
- When you need a window of detection that stretches back beyond 2-3 days.
- When you want to be certain about drug use or abstinence - hair tests are 5-10 times more sensitive than urinalysis.
- When you would like to monitor a person with a known drug history over a period of time, but don't want to be taking tests every two or three days.
- When a urine test is not acceptable for reasons of dignity.
When should I NOT choose a hair test?
- When you need to know if someone has taken drugs in the last 24 hours - 3 days.
- When you need a continuous timeline of drug use measured in days not in months.
Analyse one section of hair, say 3cm long, and that provides a picture
of someone's drug history over approximately 3 months - not a weekend
or a particular day that drugs were taken. You can define the likely month
the drug was taken by analysing each centimetre of hair separately. Top
I have read that cannabis cannot be detected in hair. Is this true?
No. Cannabis is certainly more difficult to detect in hair but for some
years TrichoTech has been developing techniques that have steadily increased
the sensitivity so that we can now reliably determine the presence of
cannabis constituents in hair. We test for three constituents of cannabis.
These are tetrahydrocannabinol (THC), Cannabidiol (CBD) and Cannabinol
(CBN) and we also test for two further metabolites of THC, that is 11-hydroxy-delta9
THC and 11 nor-delta9-THC-9-carboxylic acid. These latter two metabolites
are converted from THC after cannabis has been consumed and are therefore
markers of actual consumption whereas the finding of THC, CBD and CBN
can only prove an association with cannabis. Increased concentrations
can indicate that active consumption is more likely than passive smoking.
Top
Will the use of chemicals on hair affect the results?
Chemical treatment of the hair such as hair dye, bleach, chemical straightening
and permanent waves can damage the hair. This damage may lead to some
of any drugs that may be present, being leached out from the hair, therefore
treated hair may hold less drug than if the hair had not been treated.
As a result, it is possible that low or single use of any drugs may not
be detected. More frequent use of drugs can still be detected but the
concentration found may be less than that detected in untreated hair.
Top
How much hair is needed for a test?
About 50 strands are required from the head, about the width of a thin
pencil, or the tip of a shoe lace. There are approximately 100 000 strands
of hair on average on a person's head, so this should not make any cosmetic
difference, unless the hair is very short (see below). Top
What if the donor has little or no head hair?
Even shavings from a very short ('number one') haircut can be tested,
for a profile of drug use of about a week. If the donor has no head hair
then hair from other parts of the body can be analysed - beard, armpit,
chest or pubic hair. Someone who has shaved their head prior to a test
can therefore still provide a sample. If the donor objects or has shaved
all body hair - well, they can be offered the alternative: observed urine
tests twice weekly for 3 months!
Top
What is the time period a standard test covers, and what variations can I request?
The most common test requested
is for a 3 months/90 day history or profile of drug use or abstinence,
requiring a 3 cm (1 ¼ inches) length of hair sample. We can, however, test
from less than one centimetre up to any length of hair sample available,
though we have to cut long samples into maximum 3 cm length sections,
to maintain the test's sensitivity. Drug use profiles are therefore available
from approximately 7 or 8 days history through to over 2 years.
TrichoTech has provided clients in medical-legal fields with 2-year profiles on a
number of occasions for donors with hair 24 cm in length. Testing a centimetre
at a time is more expensive but will provide a month-by-month history,
especially useful when assessing progress of treatment or when a more
precise view of when drug use occurred is required.Top
Do hair tests discriminate between fair haired and dark haired people?
No. It is a scientific fact that dark hair can take up more of some drugs
than fair hair, but the differences are very small. Large population studies
of hair testing have shown that there is no racial or colour bias when
urine and hair tests are compared side by side. For example, a very large
cocaine study published in January 2001 considered over 56 000 samples
and found no significant relationship between hair colour and likelihood
to test positive. Our own experience testing over 15 000 hair samples
is similar; we examine and record the colour of each sample. Results from
hair testing provide a higher degree of accuracy about drug use or abstinence
than urinalysis. Factor in the large potential for fraud and evasion of
urine testing, not forgetting the 'dignity' element for the donor, and
hair analysis remains a powerful, safer choice for the testing and treatment
of drug addiction. Top
What about civil liberties?
There are many medical and legal reasons why drug tests are carried out,
but there is an increasing use of testing in the workplace too, and this
has rightly generated considerable debate on civil liberties. Testing
for drugs in the workplace should be part and parcel of a drugs and alcohol
policy, agreed between management and staff - it is after all in both
parties' interests not to have a health, safety, criminal, or performance-related
risk present at work but ignored. All tests for problem drug use should
be taken with the donor's consent. Finding the balance between an individual's right and social behaviour
and the need to protect people from possible harm to themselves or others
is important. Neither the issue of civil liberties nor that of problem
drug use should be ignored - models of good practice that show that appropriate
solutions can be achieved should be made widely available. Top
What studies have been published on hair testing?
The regular monitoring of drug users by the use of hair analysis started
with an article in a medical science journal in 1979. Since then over
400 papers have been published on the use of hair analysis in Forensic
Science International, The Lancet, British Journal of Psychiatry, Therapeutic
Drug Monitoring, Journal of Analytical Toxicology, International Journal
of Legal Medicine, European Journal of Clinical Pharmacology, American
Journal of Drug and Alcohol Abuse, International Journal of Drug Testing,
Journal of Forensic Science, Clinical Toxicology, Journal of Pharmaceutical
Science, New York Academy of Medicine, Folio Pharmacologica, Japonica.
Top
Can passive smoking have an effect on results?
It is extremely unlikely
that a positive drugs test could be the result of passive smoking. Smoke
from drugs inhaled by a non-drug user can deposit small amounts of that
drug in their system but this is far below the cut-off levels we apply
to our results in order to protect the donor from such a possibility.
The hair samples are also washed prior to extraction to eliminate any
environmental contamination. Top
How can you detect the difference between over-the counter drugs and illegal substances?
As an example, Heroin and Codeine (an over the counter remedy) have different
molecular masses and different chemical structures, so they both travel
through the GC-MS analyser at different times. The analyst will identify
the illegal drug from the over the counter drug, by looking at the time
drugs took to travel through the GC-MS analyser and its chemical structure.
Each drug has its own unique chemical structure which is then used to
identify the drug. Top


